Cohesin and chromosome segregation
نویسندگان
چکیده
منابع مشابه
Chromosome segregation: how to open cohesin without cutting the ring?
Chromosome segregation is triggered when the ring-shaped chromosomal cohesin complex is opened by proteolytic cleavage to release pairs of sister chromatids. Even before this dramatic event in anaphase, many cohesin rings lead a dynamic life on chromosomes, and in metazoan cells a good part of them dissociate from chromosome arms during mitotic prophase. Two new papers in The EMBO Journal addre...
متن کاملSystematic Reduction of Cohesin Differentially Affects Chromosome Segregation, Condensation, and DNA Repair
Cohesin's complex distribution on chromosomes and its implication in numerous cellular processes makes it an excellent paradigm for studying the relationship between the in vivo concentration of a protein and its in vivo function. Here, we report a method to generate systematic quantized reductions (QR) in the in vivo concentration of any yeast protein. With QR, we generate strains with 13% and...
متن کاملFission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase
Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation. It has been recently recognized that another type of protein modification - neddylation - may also regulate mitosis and chromosome segregation. The conserved protein DCN1 (defective cullin neddylation 1) has been shown,...
متن کاملPds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.
Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated...
متن کاملCohesin in determining chromosome architecture.
Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2018
ISSN: 0960-9822
DOI: 10.1016/j.cub.2018.05.019